Results of a pilot sequential multiple assignment randomized trial using counseling to augment a digital weight loss...

Area of Science:

• Behavioral Science
• Digital Health
• Obesity Research

Background:

• Adaptive interventions can enhance behavioral weight loss programs.
• Optimal treatment combinations for these adaptive interventions are currently unknown.
• A pilot study investigated adaptive strategies for digital weight loss.

Purpose of the Study:

• To test the timing and dose of human support in a digital weight loss program.
• To assess the feasibility and acceptability of an adaptive intervention design.
• To explore preliminary outcomes of weight loss and adherence.

Main Methods:

• A two-stage pilot sequential multiple assignment randomized trial was conducted.
• Participants were randomized to different levels of human support.
• Early non-responders were re-randomized to different intervention intensities.

Main Results:

• The study met all feasibility and acceptability criteria.
• Early responders showed significantly greater weight loss compared to non-responders.
• While outcomes were similar across treatments, more counseling participants achieved 5% weight loss.

Conclusions:

• Identifying early responders is key to optimizing weight loss interventions.
• Further research is required to develop effective rescue treatments for early non-responders.