Complex karyotypes in hematologic disorders: a 12-year single-center study from Lebanon

Area of Science:

• Cytogenetics
• Hematologic Disorders
• Genomics

Background:

• Conventional cytogenetic analysis is vital for diagnosing hematologic disorders.
• A complex karyotype (CK) involves multiple chromosomal alterations, but lacks a precise definition.
• Limited research exclusively focuses on complex karyotypes.

Purpose of the Study:

• To analyze complex karyotypes (CK) and their associated chromosomal abnormalities (CA).
• To investigate the prevalence of different anomalies within CK.
• To highlight the role of conventional cytogenetics in identifying CK.

Main Methods:

• Retrospective analysis of 255 complex karyotypes over 12 years.
• Data collected from the Center for Medical Genetics and Genomics (CGGM) in Beirut, Lebanon.
• Identification and categorization of chromosomal abnormalities associated with CK.

Main Results:

• Out of 255 patients, 59.22% were male with a mean age of 59 years.
• Hyperdiploidy was the most frequent anomaly associated with CK (22.41%).
• This study represents the largest series of CK analyzed, especially in the Middle East.

Conclusions:

• Conventional cytogenetics is essential for detecting complex karyotypes (CK).
• Findings contribute to a better understanding and management of hematologic disorders.
• Further research on complex karyotypes is warranted.