Tooth Sensitivity Following Hydrogen Peroxide Bleaching With and Without Ozone: A Randomized Controlled Trial: Tooth...

Aims: The aim of this investigation was to assess bleaching sensitivity following bleaching using either 38% H₂O₂ only or 38% H₂O₂ followed by ozone application. Methods: In this randomized controlled clinical investigation, 80 participants (40 females and 40 males) were randomly assigned to two groups (n = 40 each; 20 females and 20 males). The upper anterior teeth were bleached by 38% H₂O₂ for 20 min followed by ozone application for 60 s (healOzone X4, KaVo Dental, Biberach, Germany) in Group 1 (test group). Meanwhile, the bleaching protocol in Group 2 (controls) included the application of just 38% H₂O₂ for 20 min. Tooth sensitivity before and after bleaching was reported by the participants using a visual analog scale (VAS) from 0 to 10. Mann-Whitney U test, Wilcoxon signed-rank test, and regression analysis were used to analyze the data. Significant statistical outcomes were identified at p < 0.05. Results: Bleaching sensitivity was reported following both tested bleaching protocols (p < 0.001). However, less bleaching sensitivity was reported when ozone was applied for 60 s after bleaching with 38% H₂O₂ (p < 0.001). Female participants reported more bleaching sensitivity regardless the applied bleaching protocol (p < 0.05). Conclusions: Bleaching protocols with 38% hydrogen peroxide were associated with less bleaching sensitivity when followed by ozone application on the teeth.