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Identification of Potential Biomarkers in Papillary Thyroid Carcinoma Based on Proteomics
Yu Sun1, Jiaxuan Sun1, Xiaona Gao1
1Department of Thyroid Surgery, The Second Affiliated Hospital, Harbin Medical University, Harbin, People's Republic of China.
Background:
To identify biomarkers of papillary thyroid carcinoma (PTC) and explore the possible pathogenic mechanism.
Methods:
This study included five patients with PTC. Protein expression of cancer tissues and adjacent normal thyroid tissues from each patient were analyzed by TMT proteomics technology. Differentially expressed proteins were identified, and functional annotation of differentially expressed proteins was performed by bioinformatics and pathway enrichment analysis.
Results:
A total of 639 differentially expressed proteins were identified, including 278 upregulated and 361 downregulated proteins. Six upregulated proteins were identified as potential specific markers of PTC.
Conclusion:
Differentially expressed proteins may represent new molecular markers of PTC. These differentially expressed proteins and the related pathways may provide new insights into the pathogenic mechanisms of PTC.
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