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Updated: Jun 8, 2025
Assessment of Vascular Function in Patients With Chronic Kidney Disease
Published on: June 16, 2014
Age Differences in the Correlation Between the Cardiometabolic Index and Chronic Kidney Disease Risk in Adults With
Yu Tao1,2,3, Tao Wang2,3,4, Wei Zhou2,3,4
1Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China.
Insights
The cardiometabolic index (CMI) is linked to chronic kidney disease (CKD) risk in elderly hypertensive patients. This association was not found in younger adults with hypertension, suggesting age-specific CMI relevance for CKD.
Area of Science:
- Nephrology
- Cardiology
- Public Health
Background:
- Limited research exists on the cardiometabolic index (CMI) and chronic kidney disease (CKD) risk, particularly in hypertensive individuals.
- The cardiometabolic index, derived from waist-to-height and lipid ratios, is a potential indicator of metabolic dysfunction.
Purpose of the Study:
- To investigate the association between the cardiometabolic index (CMI) and the risk of developing chronic kidney disease (CKD) in a hypertensive population.
- To determine if this association differs between younger and elderly hypertensive adults.
Main Methods:
- A cross-sectional study involving 13,717 hypertensive individuals.
- CMI calculated using waist-to-height ratio and triglyceride-to-high-density lipoprotein cholesterol ratio.
- CKD defined by estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m².
Main Results:
- CKD prevalence was 4.24% in adults < 65 years and 14.93% in adults ≥ 65 years.
- In elderly hypertensives (≥ 65 years), CMI was independently associated with increased CKD risk (OR 1.29, 95% CI: 1.14, 1.46).
- No significant association between CMI and CKD risk was found in younger hypertensives (< 65 years) (OR 1.04, 95% CI: 0.85, 1.27).
Conclusions:
- The cardiometabolic index is an independent risk factor for CKD in elderly hypertensive individuals.
- Age is a significant factor in the relationship between CMI and CKD risk among those with hypertension.
- Further research may explore targeted CMI monitoring for CKD prevention in older hypertensive populations.
Abstract:
Literature on the association between the cardiometabolic index (CMI) and chronic kidney disease (CKD) risk is limited, especially in hypertensive populations. The objective of the present investigation was to assess the relationship between the CMI and CKD risk in a hypertensive population. The current cross-sectional study included a total of 13 717 individuals with hypertension. The calculation of the CMI was based on the waist-to-height ratio and the triglyceride-to-high-density lipoprotein cholesterol ratio. The definition of CKD was based on an estimated glomerular filtration rate (eGFR) of less than 60 mL/min/1.73 m2. The prevalence of CKD was found to be 4.24% in younger adults (aged < 65 years) and 14.93% in the elderly (aged ≥ 65 years). The results of the multivariate regression analysis indicated that in the elderly group, the CMI was positively associated with CKD risk (odd ratio [OR] 1.29; 95% confidence interval [CI]: 1.14, 1.46), while no significant relationship was observed in the younger group (OR 1.04, 95% CI: 0.85, 1.27). Furthermore, subgroup analyses did not identify any potential factors that could modify the relationship between the CMI and CKD risk (all p for interaction > 0.05). Among adults with hypertension, there was an independent and positive correlation between the CMI and CKD risk in the elderly, whereas such a correlation was not observed in younger adults. Trial Registration: ClinicalTrials.gov identifier: ChiCTR1800017274 [China Hypertension Registry Study].
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