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Endoplasmic Reticulum Stress in Bronchopulmonary Dysplasia: Contributor or Consequence?

Tzong-Jin Wu1,2, Michelle Teng1,2, Xigang Jing1,2

  • 1Department of Pediatrics, Medical College of Wisconsin, Suite C410, Children Corporate Center, 999N 92nd Street, Milwaukee, WI 53226, USA.

Cells
|November 8, 2024
PubMed

Insights

Endoplasmic reticulum (ER) stress contributes to bronchopulmonary dysplasia (BPD) in premature infants. Chemical chaperones and N-acetyl-lysyltyrosylcysteine amide (KYC) show promise in mitigating ER stress and BPD progression.

Area of Science:

  • Neonatal Medicine
  • Cellular Biology
  • Pharmacology

Background:

  • Bronchopulmonary dysplasia (BPD) is a major complication of prematurity, driven by oxidative stress and inflammation.
  • Endoplasmic reticulum (ER) stress, triggered by oxidative stress, impairs cellular functions vital for lung development, including protein synthesis and metabolic homeostasis.
  • ER stress contributes to BPD pathogenesis, leading to cellular senescence and impaired organ growth.

Purpose of the Study:

  • To review the role of ER stress in the development of BPD.
  • To discuss the therapeutic potential of chemical chaperones and N-acetyl-lysyltyrosylcysteine amide (KYC) in managing BPD.

Main Methods:

  • Literature review focusing on the mechanisms of ER stress in BPD.
  • Analysis of studies investigating chemical chaperones and KYC as therapeutic agents.
  • Examination of evidence linking ER stress to cellular senescence in the context of BPD.

Main Results:

  • ER stress is a key factor in BPD development, as demonstrated by animal models.
  • Chemical chaperones can attenuate BPD but do not fully resolve ER stress-induced senescence.
  • N-acetyl-lysyltyrosylcysteine amide (KYC), a myeloperoxidase inhibitor, effectively reduces ER stress and cellular senescence.

Conclusions:

  • ER stress is a significant contributor to BPD pathogenesis.
  • Chemical chaperones offer partial therapeutic benefits for BPD.
  • KYC presents a promising therapeutic strategy for BPD by targeting ER stress and senescence.

Keywords:
N-acetyl-lysyltyrosylcysteine amidebronchopulmonary dysplasiacellular senescencechaperoneendoplasmic reticulum stressproteostasisunfolded protein response

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