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Author Spotlight: Impact of Intergenic Interactions on Disease-Identifying Dark Biomarkers
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Regulatory Mechanism of Protein Crotonylation and Its Relationship with Cancer

Siyi Yang1,2, Xinyi Fan3, Wei Yu1,2

  • 1Institute of Biochemistry, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China.

Cells
|November 8, 2024
PubMed

Insights

Protein crotonylation, a distinct modification, is increasingly linked to various diseases. This review details its regulatory mechanisms and connection to eight common cancers, highlighting potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Crotonylation is a recently identified post-translational modification.
  • It shares enzymes with acetylation but has unique regulatory functions.
  • Numerous crotonylation sites have been found in histones and other proteins since 2011.

Purpose of the Study:

  • To review the discovery and regulatory mechanisms of protein crotonylation.
  • To explore the roles of writer, reader, and eraser proteins in crotonylation.
  • To emphasize the link between dysregulated crotonylation and common malignancies.

Main Methods:

  • Literature review of studies on protein crotonylation.
  • Analysis of regulatory proteins (writers, readers, erasers).
  • Examination of crotonylation's role in various cancers.

Main Results:

  • Crotonylation has distinct regulatory mechanisms and biological functions.
  • Dysregulated protein crotonylation is associated with eight common malignancies.
  • Specific examples include cervical, prostate, liver, and lung cancer.

Conclusions:

  • Protein crotonylation is a significant regulatory mechanism.
  • Its dysregulation presents potential therapeutic targets for cancer treatment.
  • Further research into crotonylation is warranted for disease intervention.
Keywords:
cancerprotein crotonylationregulatory mechanisms

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