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Microorganisms in Medicine and Therapeutics01:29

Microorganisms in Medicine and Therapeutics

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Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits.  Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
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Paramyxoviruses for Tumor-targeted Immunomodulation: Design and Evaluation Ex Vivo
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VEGF-Virus Interactions: Pathogenic Mechanisms and Therapeutic Applications.

Cristina Sánchez-Martínez1, Esther Grueso1, Tania Calvo-López2,3,4

  • 1Biosciences Research Institute, School of Experimental Sciences, Universidad Francisco de Vitoria, Pozuelo de Alarcón, 28223 Madrid, Spain.

Cells
|November 8, 2024
PubMed
Summary

Viruses impact vascular endothelial growth factor (VEGF) in disease and therapy. Engineered viral vectors offer new treatments for cancer and eye diseases by modulating VEGF signaling.

Keywords:
AAV vectorsVEGFVEGF peptidesangiogenesisbevacizumaboncolytic virusestumor virusesviral capsids

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Area of Science:

  • Virology
  • Molecular Biology
  • Immunology

Background:

  • Viruses interact with the vascular endothelial growth factor (VEGF) system, crucial for blood vessel formation.
  • These interactions can cause diseases or be harnessed for therapeutic purposes.

Purpose of the Study:

  • To review the literature on virus-VEGF interactions in disease pathogenesis and therapeutic applications.
  • To highlight molecular mechanisms underlying these interactions.

Main Methods:

  • Literature review of studies on viral modulation of VEGF.
  • Analysis of viral mechanisms affecting VEGF signaling pathways.
  • Examination of therapeutic viral vector applications.

Main Results:

  • Viruses can alter VEGF levels, promote angiogenesis, or disrupt vascularization, contributing to various pathologies.
  • Viral vectors are developed to inhibit VEGF in cancer and modulate it for neovascular eye diseases.
  • Engineered viruses can induce immune responses or deliver neutralizing antibodies against VEGF.

Conclusions:

  • Understanding virus-VEGF interactions is key for developing novel therapies.
  • Therapeutic virus vectors show promise for precision medicine targeting the VEGF system.
  • Further research can enhance the clinical application of these viral vectors.