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Microanalytical techniques for boron analysis using the 10B(n,alpha)7Li reaction.

R G Fairchild, D Gabel, B H Laster

    Medical Physics
    |January 1, 1986
    PubMed
    Summary
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    Accurate boron concentration measurement is crucial for neutron capture therapy (NCT) efficacy. Prompt-gamma ray detection offers a reliable method for analyzing boron in tissues and small biomolecule samples.

    Area of Science:

    • Nuclear Physics
    • Medical Physics
    • Analytical Chemistry

    Background:

    • Neutron capture therapy (NCT) efficacy relies on precise boron concentration measurement in tissues.
    • Traditional methods for trace boron analysis (1-100 ppm) are often unreliable for specific boron compounds like polyhedral boranes and carboranes.
    • Direct, nondestructive physical detection of boron is preferred over radiolabeling for accurate quantification.

    Purpose of the Study:

    • To present reliable methods for measuring boron concentration in tissues for NCT.
    • To describe prompt-gamma ray detection facilities for boron analysis.
    • To introduce a track-etching technique for analyzing trace boron in small biological samples.

    Main Methods:

    • Utilized prompt-gamma ray detection from the 10B(n, alpha)7Li reaction for boron analysis.

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  • Developed two prompt-gamma facilities at Brookhaven National Laboratory, one at a high flux beam reactor and another at a medical research reactor.
  • Employed a track-etching technique for detecting nanogram amounts of boron in milligram samples of biomolecules or cell cultures.

    • Main Results:

    • Prompt-gamma ray detection proved to be a reliable technique for boron analysis.
    • The developed facilities enable both high-intensity neutron analysis and on-line boron monitoring for NCT.
    • The track-etching method successfully quantified trace boron in small biological samples, including antibodies and cell cultures.

    Conclusions:

    • Prompt-gamma ray analysis is a dependable method for determining boron concentration essential for NCT.
    • The described facilities and techniques support the clinical application and development of boronated compounds for NCT.
    • Accurate boron quantification in small samples is achievable, facilitating research on boronated biomolecules and cellular uptake.