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Related Experiment Videos

Plasma creatine kinase changes after eccentric and concentric contractions.

D J Newham, D A Jones, R H Edwards

    Muscle & Nerve
    |January 1, 1986
    PubMed
    Summary

    Eccentric contractions, not concentric ones, cause the significant delayed rise in creatine kinase (CK) enzyme levels after exercise. This finding clarifies the cause of exercise-induced muscle damage and enzyme release.

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    Area of Science:

    • Exercise Physiology
    • Muscle Physiology
    • Biochemistry

    Background:

    • A significant delayed rise in plasma creatine kinase (CK) levels is observed in normal subjects following strenuous exercise.
    • The specific type of muscle contraction (eccentric vs. concentric) responsible for this delayed enzyme efflux has not been definitively established.

    Purpose of the Study:

    • To investigate whether eccentric or concentric muscle contractions are responsible for the large delayed rise in creatine kinase (CK) levels after exercise.
    • To differentiate the effects of predominantly eccentric versus concentric contractions on plasma CK activity.

    Main Methods:

    • Five healthy subjects performed equivalent workloads on a 13-degree inclined treadmill, engaging in either uphill walking (predominantly concentric contractions) or downhill walking (predominantly eccentric contractions).

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  • Plasma CK levels were measured at timed intervals post-exercise to assess the magnitude and timing of enzyme release.

    • Main Results:

    • Uphill walking (concentric) resulted in a modest peak plasma CK of 60-200 IU/liter at 24 hours post-exercise.
    • Downhill walking (eccentric) induced a substantially larger peak plasma CK of 700-1500 IU/liter, occurring 4-7 days after exercise.

    Conclusions:

    • Eccentric muscle contractions are the primary cause of the large, delayed increase in plasma creatine kinase (CK) levels observed after exercise.
    • This finding highlights the significant role of eccentric contractions in inducing muscle damage and subsequent enzyme release.