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Related Experiment Video

Updated: Jun 8, 2025

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

[Viral retinitis].

S Touhami¹, A Toutée², Y-R Chung³

¹Service d'ophtalmologie, Sorbonne université, CHU Pitié-Salpêtrière, Paris, France; Inserm, CNRS, institut de la vision, Sorbonne université, Paris, France.

Journal Francais D'Ophtalmologie

|November 8, 2024

Summary

This summary is machine-generated.

Herpes viruses like HSV, VZV, and CMV cause necrotizing retinitis, presenting as ARN, PORN, or CMV retinitis. Early treatment is crucial to prevent vision loss from these viral eye infections.

Keywords:

ARN CMV HSV Herpes Herpès Nécrose rétinienne Névrite optique Optic neuritis Optic neuropathy PORN Retinal necrosis Retinitis Rétinite VZV Virus

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Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

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Using Adeno-associated Virus as a Tool to Study Retinal Barriers in Disease

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Area of Science:

Ophthalmology
Virology
Infectious Diseases

Context:

Herpes family viruses, including herpes simplex virus (HSV) 1 and 2, varicella zoster virus (VZV), and cytomegalovirus (CMV), are primary etiologies of necrotizing retinitis.
Necrotizing retinitis presents in three main clinical forms: acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN), and CMV retinitis, often influenced by the patient's immune status.

Purpose:

To highlight the leading viral causes of necrotizing retinitis.
To differentiate the clinical manifestations of viral retinal necrosis based on immune status.
To emphasize the importance of timely therapeutic intervention in managing these sight-threatening conditions.

Summary:

Herpesviruses are the principal agents responsible for necrotizing retinitis.
Clinical presentations include ARN, PORN, and CMV retinitis, with variations linked to patient immunity.
Effective antiviral therapies exist, but prompt initiation is critical for visual prognosis.

Impact:

Early diagnosis and treatment of viral retinitis can prevent irreversible vision impairment.
Understanding the specific viral culprits and their clinical patterns aids in targeted therapeutic strategies.
Advances in antiviral medications offer hope for better outcomes in patients with herpes-related retinal necrosis.