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Updated: Jun 8, 2025

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
Published on: August 7, 2015
[Viral retinitis]
S Touhami1, A Toutée2, Y-R Chung3
1Service d'ophtalmologie, Sorbonne université, CHU Pitié-Salpêtrière, Paris, France; Inserm, CNRS, institut de la vision, Sorbonne université, Paris, France.
Abstract:
Viruses belonging to the herpes family group, including HSV (herpes simplex virus) 1 and 2, VZV (varicella zoster virus) and CMV (cytomegalovirus) are the leading causes of necrotizing retinitis. These viral retinal necroses generally manifest in three forms, depending on the patient's immune status: acute retinal necrosis (ARN), progressive outer retinal necrosis (PORN) and CMV retinitis. Although specific, effective drug treatments are available today, early treatment initiation is essential to avoid sight-threatening complications.
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