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Updated: Jun 12, 2025

A Microbiomechanical System for Studying Varicosity Formation and Recovery in Central Neuron Axons
Published on: April 30, 2018
Interplay of force and local mechanisms in axonal plasticity and beyond
1Division of Neuroscience, Department of Brain Sciences, Imperial College London, London, UK; Department of Biology, Universiy of Pisa, Pisa, Italy.
Abstract:
The interactions between mechanical forces and neuronal dynamics have long intrigued researchers. Several studies revealed that force plays a pivotal role in shaping axonal outgrowth. However, the molecular mechanisms underpinning force-driven axonal plasticity remain not completely elucidated. This review explores the relationship between force and axonal plasticity, with a focus on local mechanisms, including local translation and axonal transport, and the emerging concept of force-driven cross-talk, a dialogue in which local dynamics are tightly regulated. Recent experimental evidence suggests that microtubules may serve as key mediators of this cross-talk, orchestrating the coordination between local mechanisms and facilitating mass addition.
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