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A Comprehensive Procedure to Evaluate the In Vivo Performance of Cancer Nanomedicines
Published on: March 4, 2017
Transforming cancer treatment: The potential of nanonutraceuticals
Girish Kumar1, Tarun Virmani1, Vaishnavi Chhabra2
1Amity Institute of Pharmacy, Amity University Greater Noida, Uttar Pradesh 201308, India.
Abstract:
Chemotherapy in the management of cancer is constrained by limitations like off-target effects, poor bioavailability, and dose-dependent toxicity. Nutraceuticals have been explored as an innovative strategy to overcome chemotherapy drawbacks.However, the clinical utility of nutraceuticals is restricted due to their complex structures, less water solubility, reduced stability, decreased bioavailability and more obstacles in the gastrointestinal tract. Nanonutraceuticals are nanosized nutraceutical particles having enhanced solubility, improved bioavailability, stability, and targeted delivery to specific cells. Nutraceuticals can be co-delivered with other chemotherapeutic drugs in nanocarriers to elicit synergistic effects. The targeting of nutraceuticals against cancer cells can be enabled by coupling ligands with the nanocarriers, which direct to the overexpressed receptors found at the surface of the cancer cells. Transitioning a nanonutraceutical from pre-clinical research to clinical trials is a pivotal step. This focus on advancing their application holds great potential for impacting clinical research and improving the treatment landscape for cancer patients. This review focuses on the role of nutraceuticals for cancer treatment, various nanocarriers for the efficient delivery of nutraceuticals along with co-administration of nutraceuticals with chemotherapeutic drugs using nanocarriers. Also, emphasize the targeting of ligands coupled nanocarriers to the cancer cells along with patents and clinical trials for nanonutraceuticals.
Insights
Nanonutraceuticals offer improved delivery and efficacy for cancer treatment by overcoming limitations of traditional nutraceuticals and chemotherapy. This review explores their potential, nanocarrier systems, and targeted delivery strategies for enhanced cancer therapy.
Area of Science:
- Oncology
- Nanotechnology
- Pharmacology
Background:
- Chemotherapy faces challenges including off-target effects, poor bioavailability, and toxicity.
- Nutraceuticals show promise for cancer treatment but have limited clinical utility due to poor solubility and stability.
- Nanonutraceuticals, engineered at the nanoscale, enhance solubility, bioavailability, stability, and enable targeted delivery.
Purpose of the Study:
- To review the role of nutraceuticals in cancer treatment.
- To explore various nanocarriers for efficient nutraceutical delivery.
- To discuss co-administration of nutraceuticals with chemotherapy using nanocarriers and targeted delivery strategies.
Main Methods:
- Literature review focusing on nanonutraceuticals in cancer therapy.
- Analysis of nanocarrier systems for nutraceutical delivery.
- Examination of ligand-targeted nanocarriers for cancer cell specificity.
Main Results:
- Nanonutraceuticals demonstrate enhanced properties for cancer treatment.
- Co-delivery of nutraceuticals and chemotherapeutics via nanocarriers can yield synergistic effects.
- Ligand-targeted nanocarriers improve precision in delivering nutraceuticals to cancer cells.
Conclusions:
- Nanonutraceuticals represent a significant advancement in cancer therapy, addressing limitations of conventional treatments.
- Targeted delivery systems and co-administration strategies hold great potential for improving clinical outcomes.
- Further research and clinical trials are crucial for translating nanonutraceuticals into effective cancer treatments.
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