Related Experiment Video
Updated: Jun 8, 2025
Murine Model of Allergen Induced Asthma
Published on: May 14, 2012
Nasal allergen challenge with Blomia tropicalis in children and adolescents
Fausto Yoshio Matsumoto1, Tessa Rachel Tranquilini Gonçalves2, Dirceu Solé2
1Division of Allergy, Clinical Immunology and Rheumatology, Department of Pediatrics, Universidade Federal de São Paulo, São Paulo, Brazil; alergiaimunoreumatologia@unifesp.br.
Background:
Local allergic rhinitis (LAR) is a well-defined phenotype in adults, but still there is little data available on children. This scarcity of data can be partly attributed to the lack of standardized protocols for Nasal Allergen Challenges (NAC) in this demographic.
Methods:
20 controls (control group) and 24 patients (rhinitis group) with allergic rhinitis diagnosis sensitized to Blomia tropicalis (Bt) underwent the NAC with Bt. The acoustic rhinometry was performed after instillation of increasing concentrations of Bt (5,000 BU/mL).
Results:
The median reduction in the volume of the nasal cavity in its first five centimeters (V5) by the conclusion of the NAC in the rhinitis group was markedly higher than that observed in the control group, at -22.9% (range: -21.1% to -26.2%) compared to -7.7% (ranging: -4.8% to +12.8%).
Conclusions:
Our research demonstrates the efficacy and safety of the NAC protocol utilizing Bt in distinguishing allergic from non-allergic children.
