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Unveiling the hidden power of noncoding RNAs in pediatric respiratory diseases

Shishu Yu1, Lili Chen1, Mingyao Zhang1

  • 1Department of Pediatrics, The Third Affiliated Hospital of Changchun University of Chinese Medicine, Changchun, Jilin, China.

Allergologia Et Immunopathologia
|November 8, 2024
PubMed

Insights

Epigenetic mechanisms, particularly noncoding RNAs (ncRNAs), are crucial in pediatric respiratory diseases. This review details the roles of long noncoding RNAs, microRNA, and circular RNA in these conditions.

Area of Science:

  • Pediatric respiratory medicine
  • Epigenetics
  • Molecular biology

Background:

  • Pediatric respiratory diseases significantly affect children's health and quality of life.
  • Epigenetic mechanisms are increasingly recognized as key factors in disease development.
  • Noncoding RNAs (ncRNAs) are implicated in various human diseases.

Purpose of the Study:

  • To review the regulatory functions of specific ncRNAs in pediatric respiratory diseases.
  • To highlight the association between ncRNA mutations/expression and disease development.
  • To provide insights into the epigenetic basis of childhood respiratory conditions.

Main Methods:

  • Literature review focused on noncoding RNAs.
  • Analysis of studies investigating long noncoding RNAs, microRNA, and circular RNA.
  • Synthesis of current research on ncRNA functions in pediatric respiratory diseases.

Main Results:

  • Long noncoding RNAs, microRNA, and circular RNA play significant regulatory roles.
  • Aberrant expression or mutations in these ncRNAs are linked to the development of pediatric respiratory diseases.
  • These ncRNAs are critical components of the epigenetic landscape in these conditions.

Conclusions:

  • ncRNAs are vital regulators in the pathogenesis of pediatric respiratory diseases.
  • Understanding ncRNA functions offers potential therapeutic targets.
  • Further research into ncRNA mechanisms is warranted for improved pediatric respiratory health.

Keywords:
biomarkernoncoding RNAspediatric respiratory diseasesrespiratory system

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