Effect of perioperative dexmedetomidine on postoperative delirium in patients with brain tumours: a protocol of a randomised controlled trial
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View abstract on PubMed
Summary
This summary is machine-generated.This study investigates if dexmedetomidine can reduce postoperative delirium in patients undergoing brain surgery for temporal glioma. Results will determine its effectiveness in neurosurgery patients.
Area Of Science
- Neurosurgery
- Anesthesiology
- Neuroscience
Background
- Neurosurgery poses a significant risk for developing postoperative delirium.
- Dexmedetomidine is being explored for its potential to mitigate this complication.
- Temporal glioma resections represent a specific neurosurgical context where delirium is a concern.
Purpose Of The Study
- To evaluate the efficacy of perioperative dexmedetomidine in reducing the incidence of postoperative delirium.
- To test the hypothesis that dexmedetomidine administration lowers delirium rates in patients undergoing temporal glioma surgery.
Main Methods
- A single-center, randomized, blinded, parallel-group controlled trial involving 366 patients.
- Patients were randomized into two groups: dexmedetomidine (n=183) or placebo (n=183).
- Dexmedetomidine was administered as a continuous infusion during surgery and postoperatively for 48 hours; the placebo group received normal saline.
Main Results
- The primary outcome is the incidence of postoperative delirium.
- Delirium assessment was conducted using the Confusion Assessment Method twice daily for the first five postoperative days.
- Data collection and analysis are pending to determine the primary outcome.
Conclusions
- The study is designed to provide crucial data on dexmedetomidine's role in preventing postoperative delirium after neurosurgery.
- Findings will inform clinical practice guidelines for managing delirium in patients undergoing temporal glioma resection.
- Dissemination of results is planned through scientific conferences and peer-reviewed publications.
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