Related Experiment Video

Updated: Jun 8, 2025

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

2.7K

A systematic review and meta-analysis exploring the bidirectional association between asthma and gastroesophageal

KaiWen Zheng1, Xiang Wang1, LinYan Tang1

  • 1From the School of Clinical Medicine, Shandong Second Medical University, Weifang, Shandong, China and.

Allergy and Asthma Proceedings
|November 9, 2024
PubMed

Insights

Asthma and gastroesophageal reflux disease (GERD) in children have a two-way link, with asthma increasing GERD risk more significantly. Further research is needed to confirm this association.

Area of Science:

  • Pediatric Pulmonology
  • Pediatric Gastroenterology
  • Epidemiology

Background:

  • Asthma is a leading chronic respiratory illness in children.
  • Gastroesophageal reflux disease (GERD) is a recognized extraesophageal complication of pediatric asthma.
  • The causal relationship between asthma and GERD in children remains under investigation.

Approach:

  • A systematic review and meta-analysis were conducted to investigate the bidirectional association between asthma and GERD in pediatric populations.
  • Original studies published between January 2000 and February 2024 were systematically searched and screened.
  • Study quality was assessed using the Newcastle-Ottawa Scale, and relevant outcome measures were extracted.

Key Points:

  • Nine eligible studies encompassing 304,399 children across seven countries were included in the analysis.
  • Children with asthma exhibited a higher risk of developing GERD (OR 2.16) compared to children with GERD developing asthma (OR 1.55).
  • The findings indicate a mutually aggravating relationship between asthma and GERD in children.

Conclusions:

  • Asthma and GERD present a bidirectional association in children, acting as mutually aggravating factors.
  • The risk of developing GERD is notably higher in children with asthma.
  • High-quality, large-scale prospective cohort studies are recommended to further elucidate this relationship.

More Related Videos

Surgical Models of Gastroesophageal Reflux with Mice05:19

Surgical Models of Gastroesophageal Reflux with Mice

Published on: August 25, 2015

10.1K
Methodology for Sputum Induction and Laboratory Processing13:28

Methodology for Sputum Induction and Laboratory Processing

Published on: December 17, 2017

27.5K

Related Concept Videos

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
289
Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
54
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
Asthma-I: Introduction01:29

Asthma-I: Introduction

Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
2.6K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
109
Barrett Esophagus-I: Introduction01:21

Barrett Esophagus-I: Introduction

Barrett's esophagus is a medical condition where the esophageal mucosa is significantly damaged by stomach acid or other digestive fluids, often due to long-term exposure associated with gastroesophageal reflux disease (GERD). In GERD, a weakened or abnormally relaxed lower esophageal sphincter allows stomach acid to flow persistently into the esophagus.
This constant acid exposure transforms the esophagus's pink mucosal lining (stratified squamous epithelium) into a type of lining more...
66