Nutritional Supplement with Fermented Soy in Patients Under Active Surveillance for Low-Risk or Intermediate-Risk Prostate Cancer: Results from the PRAEMUNE Trial
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View abstract on PubMed
Summary
This summary is machine-generated.A fermented soy supplement may help manage prostate cancer (PCa) in patients on active surveillance (AS). It showed a PSA level response in over 60% of participants, potentially aiding treatment decisions.
Area Of Science
- Oncology
- Nutritional Science
- Urology
Background
- Active surveillance (AS) is a management strategy for low-risk and select favorable intermediate-risk prostate cancer (PCa).
- Monitoring prostate-specific antigen (PSA) levels and PSA velocity (PSAV) are key components of AS.
- Identifying interventions to support patients on AS is crucial for optimizing outcomes.
Purpose Of The Study
- To evaluate the efficacy of a fermented soy supplement in modulating PSA levels in PCa patients undergoing AS.
- To assess the impact of the supplement on disease progression and the need for active therapy.
Main Methods
- A 18-month study involving 150 patients with low-risk or favorable intermediate-risk PCa on AS.
- Patients received a fermented soy supplement.
- Primary outcome: PSA response (max PSA rise ≤ 0.87 ng/mL after 1 year). Secondary outcomes: disease progression, adverse histology, switch to active therapy.
Main Results
- Over 61% (92/150) of patients achieved a PSA level response.
- A significant reduction in follow-up MRIs and control biopsies was observed, particularly in ISUP grade 1 patients.
- PSA response was numerically linked to a lower likelihood of initiating active therapy.
Conclusions
- Fermented soy supplementation may be a beneficial adjunct for patients with low-risk and favorable intermediate-risk PCa on AS.
- The supplement could aid in identifying patients suitable for continued AS versus those requiring escalation of care.
- Further research can explore its role in personalized PCa management strategies.
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