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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...

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Related Experiment Video

Updated: Jun 19, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

Published on: July 17, 2012

Design Principles and Applications of Fluorescent Kinase Inhibitors for Simultaneous Cancer Bioimaging and Therapy.

Ab Majeed Ganai¹, Eirinaios I Vrettos¹, Stavroula G Kyrkou¹

¹Department of Chemistry, Section of Organic Chemistry and Biochemistry, University of Ioannina, 45110 Ioannina, Greece.

|November 9, 2024

Summary

Kinase inhibitor-fluorophore conjugates offer simultaneous cancer diagnosis and treatment by enabling tumor microenvironment imaging. This theranostic approach enhances therapeutic interventions and visualizes malignant tissues effectively.

Keywords:

bioimaging conjugates design principles kinase inhibitors theranostic agents

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Last Updated: Jun 19, 2026

Computed Tomography-guided Time-domain Diffuse Fluorescence Tomography in Small Animals for Localization of Cancer Biomarkers

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Published on: July 17, 2012

Fluorescence-quenching of a Liposomal-encapsulated Near-infrared Fluorophore as a Tool for In Vivo Optical Imaging

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Published on: January 5, 2015

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Dual Bioluminescence Imaging of Tumor Progression and Angiogenesis

Published on: August 1, 2019

Area of Science:

Oncology
Biomedical Engineering
Pharmacology

Background:

Kinase inhibitors are vital cancer therapeutics.
Imaging the tumor microenvironment is a key challenge.
Current limitations hinder effective cancer treatment monitoring.

Purpose of the Study:

To review the design principles of multimodal kinase inhibitors.
To highlight their potential in kinase tracking and inhibition via bioimaging.
To analyze structural aspects of developing theranostic agents.

Main Methods:

Literature review of kinase inhibitor-fluorophore conjugates.
Analysis of design principles for multimodal inhibitors.
Critical examination of structural aspects for theranostic agent construction.

Main Results:

Kinase inhibitor-fluorophore conjugates enable simultaneous diagnosis and treatment.
These agents visualize malignant tissues and enhance therapeutic interventions.
Multimodal inhibitors show promise for kinase tracking and inhibition.

Conclusions:

Kinase inhibitor-fluorophore conjugates are promising theranostic agents.
Further development of these compounds can advance cancer therapy.
This review provides impetus for novel theranostic compound development.