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Related Concept Videos

Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
Mitral Stenosis I: Introduction01:22

Mitral Stenosis I: Introduction

Mitral Valve Stenosis (MVS) is a heart condition where the mitral valve narrows, impeding blood circulation from the left atrium to the left ventricle. The etiology and pathophysiology of this condition are multifaceted, leading to a cascade of cardiovascular complications.Causes of Mitral Valve StenosisRheumatic Heart Disease: It is the main cause of mitral valve stenosis, particularly in developing nations. This condition arises from rheumatic fever, an inflammatory illness resulting from...
Heart Failure III: Clinical Manifestations01:26

Heart Failure III: Clinical Manifestations

Heart failure (HF) manifests primarily as dyspnea, fatigue, and fluid retention, resulting in peripheral and pulmonary edema. Symptoms may vary depending on which ventricle is more affected, left or right.Left-Sided Heart FailureAlso known as left ventricular failure, this condition results from the left ventricle's inability to fill or eject sufficient blood into the systemic circulation. It leads to pulmonary congestion, which occurs when the left ventricle fails to eject blood effectively...
Cardiomyopathy II: Dilated Cardiomyopathy01:30

Cardiomyopathy II: Dilated Cardiomyopathy

Dilated cardiomyopathy, or DCM, is a progressive myocardial disorder characterized by ventricular chamber dilation and contractile dysfunction.EtiologyVarious factors can cause DCM, including hypertension and heavy alcohol intake, which contribute to the weakening and enlargement of the heart muscle. Viral infections, such as Coxsackievirus B, adenoviruses, and influenza, can lead to DCM by causing inflammation and damage to heart tissue. Certain chemotherapeutic agents, including daunorubicin,...
Cardiomyopathy V: Interprofessional Care01:29

Cardiomyopathy V: Interprofessional Care

Managing cardiomyopathy involves addressing underlying or precipitating causes, treating heart failure with medications, and implementing dietary changes and a balanced exercise and rest regimen.Lifestyle ModificationsCardiomyopathy patients should adopt a low-sodium diet to reduce fluid retention and manage heart failure. A personalized exercise and rest plan helps maintain physical fitness without overstraining the heart. Avoiding alcohol and tobacco is essential to prevent further damage to...

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Related Experiment Video

Updated: Jul 4, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
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Left Atrial Appendage Closure in Atrial Fibrillation Patients with Cancer.

David Zweiker1,2, Jutta Bergler-Klein3, Lukas Fiedler4

  • 1Division of Cardiology, Medical University of Graz, 8036 Graz, Austria.

Journal of Clinical Medicine
|November 9, 2024
PubMed
Summary

Left atrial appendage closure (LAAC) is a safe and effective treatment for patients with cancer, showing similar outcomes to those without cancer. This study confirms LAAC

Keywords:
anticoagulationatrial fibrillationcancercardio-oncologycomplicationsleft atrial appendage closuremalignancy

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Area of Science:

  • Cardiology
  • Interventional Cardiology
  • Oncology

Background:

  • Limited data exist on left atrial appendage closure (LAAC) in cancer patients.
  • This study addresses the safety and efficacy of LAAC in this population.

Purpose of the Study:

  • To compare outcomes of LAAC in patients with and without a history of cancer.
  • To assess the relationship between baseline characteristics and outcomes in these groups.

Main Methods:

  • Sub-analysis of the prospective Austrian LAAC Registry.
  • Included 486 consecutive patients, with 57 having a history of cancer.
  • Used inverse probability weighting to adjust for baseline characteristic differences.

Main Results:

  • Cancer patients were older, with higher rates of anemia and GI bleeding.
  • No significant differences in major procedural complications (5.3% vs. 7.0%).
  • Similar 5-year survival (80.7% vs. 84.8%) and 1-year survival (96.1% vs. 94.0%) between groups.

Conclusions:

  • LAAC is an accepted treatment option for cancer patients in clinical practice.
  • Short-term and long-term outcomes of LAAC are comparable in cancer and non-cancer patients.
  • This supports the use of LAAC in selected cancer patients.