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Related Concept Videos

Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

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Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
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Open Angle Glaucoma: Treatment01:27

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In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
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Glaucoma: Overview01:25

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Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
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Updated: Jun 7, 2025

Trabecular Meshwork Response to Pressure Elevation in the Living Human Eye
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Flow-Adjusted Trabeculectomy.

Assaf Kratz1, Ivan Goldberg2,3,4, Tal Koren1

  • 1Department of Ophthalmology, Soroka University Medical Center, Faculty of Health Sciences, Ben-Gurion University of the Negev, P.O. Box 151, Beer-Sheva 8400101, Israel.

Journal of Clinical Medicine
|November 9, 2024
PubMed
Summary
This summary is machine-generated.

This study introduces a simplified flow-adjusted surgical method for trabeculectomy, demonstrating significant intra-ocular pressure (IOP) reduction and high success rates in glaucoma patients.

Keywords:
intra-operative flow adjustmenttrabeculectomy

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Area of Science:

  • Ophthalmology
  • Surgical Innovation
  • Glaucoma Management

Background:

  • Trabeculectomy is a gold standard surgical intervention for reducing intra-ocular pressure (IOP) in glaucoma.
  • Existing methods may be complex, necessitating simpler, effective alternatives.

Purpose of the Study:

  • To present a novel intra-operative flow-adjusted surgical technique for trabeculectomy and phacotrabeculectomy.
  • To evaluate the safety and efficacy of this simplified method in surgery-naïve glaucoma patients.

Main Methods:

  • Retrospective analysis of trabeculectomy or phacotrabeculectomy in 186 surgery-naïve eyes over three years.
  • Defined success based on IOP targets (5-18 mmHg) and medication reduction.
  • Failure criteria included IOP outside target range or need for re-operation.

Main Results:

  • Trabeculectomy group (45 eyes): Mean IOP reduced from 28.1 to 9.7 mmHg (66% decrease) with 88.9% success rate.
  • Phacotrabeculectomy group (35 eyes): Mean IOP reduced from 26.1 to 10.0 mmHg (62% decrease) with 91.4% success rate.
  • Both procedures showed low complication rates and significant IOP reduction (p < 0.00001).

Conclusions:

  • The intra-operative flow-adjusted trabeculectomy and phacotrabeculectomy techniques are safe and effective for lowering IOP.
  • This simplified surgical approach offers a promising option for glaucoma management.