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A Multifaceted Exploration of Status Asthmaticus: A Retrospective Analysis in a Romanian Hospital
Adriana Ana Trusculescu1,2, Versavia Maria Ancusa3, Camelia Corina Pescaru1,2
1Center for Research and Innovation in Personalized Medicine of Respiratory Diseases (CRIPMRD), Pulmology University Clinic, 'Victor Babes' University of Medicine and Pharmacy, Eftimie Murgu Square no. 2, 300041 Timisoara, Romania.
Abstract:
Background: Status asthmaticus is a severe, life-threatening asthma exacerbation requiring urgent medical intervention. This study aims to examine its epidemiology in Timis County, Romania, over 11 years. Methods: A retrospective analysis was conducted using hospital records from 2013 to 2023, focusing on demographic, geospatial, and temporal distributions. Network analysis of the recorded comorbidities was used to identify phenotypic clusters among patients. Results: Females and older adults were disproportionately affected. Several triggers and geospatial patterns were identified. Five phenotypic clusters were determined: two in the T2-high endotype, two in T2-low, and a mixed one. Conclusions: The findings highlight the need for personalized asthma management strategies and public healthcare interventions in Timiș County, addressing specific demographic and geospatial factors. This study also provides a valuable reference for similar regions.
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