Neurotensin and Its Involvement in Female Hormone-Sensitive Cancers
Ninon Bertrand1, Romane Mougel2, George Riley3
1Department of Gynecology and Obstetrics, CHRU de Nancy, Université de Lorraine, F-54000 Nancy, France.
Abstract:
Neurotensin (NT) is a peptide involved in digestion, neuromodulation, and cancer progression. NT and its receptors (NTR1 and SORT1 mainly) have been widely studied in oncology. Data show that NT expression is under the control of sex steroid hormones, in particular estradiol. We focused on its involvement in three main female hormone-sensitive cancers, breast, ovarian, and endometrial cancer, in a narrative review. NT, NTR1, and SORT1 are mostly expressed in these three cancers, and their involvement in oncologic processes such as proliferation and invasion seems to match, as does their impact on prognosis for most. The development of NT receptor-targeted therapies, including theranostics and radioligand treatments, presents a promising avenue for personalized cancer treatment.
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