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Related Concept Videos

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

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Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
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Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
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Altered...
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Factors Affecting the Risk of Infection01:26

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The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
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Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

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Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel...
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Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

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Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
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Correction: Pramesthi et al. Evaluating the Impact of Indonesia's National School Feeding Program (ProGAS) on Children's Nutrition and Learning Environment: A Mixed-Methods Approach. <i>Nutrients</i> 2025, <i>17</i>, 3575.

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Related Experiment Video

Updated: Jun 7, 2025

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Selenium, Immunity, and Inflammatory Bowel Disease.

James A Sousa1, Derek M McKay1, Maitreyi Raman2,3

  • 1Gastrointestinal Research Group, Inflammation Research Network, Department of Physiology and Pharmacology, Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, AB T2N 1N4, Canada.

Nutrients
|November 9, 2024
PubMed
Summary
This summary is machine-generated.

Selenium is an essential micronutrient vital for immune function. This review explores selenium

Keywords:
immunityinflammatory bowel diseaseseleniumselenoproteins

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Area of Science:

  • Gastroenterology and Nutritional Science
  • Immunology and Micronutrient Research

Background:

  • Rising global incidence of Inflammatory Bowel Disease (IBD) suggests environmental factors.
  • Dietary components and micronutrients are implicated in IBD pathogenesis and severity.
  • Selenium, an essential micronutrient for immune function, has been understudied in IBD.

Purpose of the Study:

  • To review the physiological and immunological roles of selenium.
  • To explore the potential role of selenium in Inflammatory Bowel Disease.
  • To identify knowledge gaps and stimulate further research on selenium in IBD.

Main Methods:

  • Literature review of physiological and immunological functions of selenium.
  • Analysis of existing studies on selenium and IBD.
  • Identification of research gaps concerning selenium deficiency in IBD patients.

Main Results:

  • Selenium deficiency is frequently observed in IBD patients.
  • Limited clinical trials exist on the impact of selenium deficiency in IBD.
  • Selenium plays a crucial role in immune system regulation.

Conclusions:

  • Further research is needed to understand selenium's role in IBD management.
  • Investigating selenium's impact on IBD pathogenesis and treatment is warranted.
  • Addressing selenium deficiency may offer a novel therapeutic avenue for IBD.