Association of PADI4 Gene Polymorphisms With Susceptibility to Rheumatoid Arthritis: Evidence From 24 Case-Control
Mohammad Karimian1, Fatemeh Zahra Mohammadzadeh2
1Department of Molecular and Cell Biology, Faculty of Basic Sciences, University of Mazandaran, Babolsar, Iran.
International Journal of Immunogenetics
|November 9, 2024
Summary
Genetic variations in the PADI4 gene, specifically rs11203366, rs11203367, rs874881, and rs1748033, are associated with an increased risk of rheumatoid arthritis (RA). Ethnicity influences the impact of these genetic factors on RA development.
Area of Science:
- Genetics
- Immunology
- Bioinformatics
Background:
- Rheumatoid arthritis (RA) is a chronic autoimmune disease with a complex genetic component.
- The protein-arginine deiminase type 4 (PADI4) gene is implicated in the pathogenesis of RA.
- Identifying specific PADI4 gene polymorphisms associated with RA risk is crucial for understanding disease mechanisms.
Purpose of the Study:
- To investigate the association between five PADI4 gene polymorphisms (rs11203366, rs11203367, rs874881, rs2240340, and rs1748033) and the risk of rheumatoid arthritis (RA).
- To explore the functional impact of these polymorphisms using bioinformatics approaches.
- To examine potential ethnic differences in the association between PADI4 polymorphisms and RA risk.
Main Methods:
- A meta-analysis of published studies was conducted to quantitatively assess the association between PADI4 polymorphisms and RA risk.
- In silico analysis using bioinformatics tools was performed to predict the functional effects of the identified polymorphisms.
- Data from reputable articles were collected and analyzed.
Main Results:
- The rs874881 polymorphism in the Latino population and the rs1748033 polymorphism in the Caucasian population were significantly associated with an increased risk of RA.
- The rs11203366 and rs11203367 polymorphisms showed a significant impact on RA risk in the Latino population.
- Bioinformatics analysis provided insights into the functional consequences of these PADI4 gene polymorphisms.
Conclusions:
- The PADI4 gene polymorphisms rs11203366, rs11203367, rs874881, and rs1748033 may serve as genetic risk factors for rheumatoid arthritis.
- Ethnic background appears to play a significant role in modulating the effect of these PADI4 polymorphisms on RA susceptibility.
- Further research is warranted to elucidate the precise mechanisms by which these polymorphisms contribute to RA pathogenesis.
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