Related Experiment Video

Updated: Jul 11, 2026

In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue
06:59

In Vivo Evaluation of the Mechanical and Viscoelastic Properties of the Rat Tongue

Published on: July 6, 2017

8.7K

Hypoglossal Nerve Stimulation Outcomes in Pediatric Trisomy 21 Patients with Overweight or Obesity

Jeffrey C Mecham1, Hannah Gibbs1, Trenton House2

  • 1Department of Otolaryngology, Head and Neck Surgery, Mayo Clinic, Phoenix, Arizona, U.S.A.

The Laryngoscope
|November 9, 2024
PubMed

Insights

Body mass index (BMI) does not impact hypoglossal nerve stimulator (HNS) outcomes in pediatric patients with Down syndrome. Obese and non-obese children with Down syndrome showed similar favorable responses to HNS therapy.

Area of Science:

  • Pediatric Otolaryngology
  • Sleep Medicine
  • Genetics

Background:

  • Obstructive sleep apnea (OSA) is prevalent in pediatric patients with Down syndrome (DS).
  • Hypoglossal nerve stimulator (HNS) implantation is an emerging treatment for OSA in this population.
  • The impact of body mass index (BMI) on HNS outcomes in pediatric DS patients is not well-established.

Purpose of the Study:

  • To evaluate the association between BMI and HNS implantation outcomes in pediatric patients with Down syndrome.
  • To compare HNS outcomes between overweight/obese and non-obese pediatric DS patients.

Main Methods:

  • Retrospective cohort study of pediatric patients (<21 years) with DS who underwent HNS implantation (2022-2024).
  • Patients were categorized based on BMI percentile (overweight/obese vs. non-obese).
  • Primary outcome was the reduction in apnea-hypopnea index (AHI) post-implantation.

Main Results:

  • Twenty patients (11 overweight, 8 obese) received HNS implants.
  • No significant correlation was found between BMI percentile and AHI reduction (r=0.06, p=0.8).
  • Obese and non-obese groups showed comparable preoperative AHI, postoperative AHI, and AHI reduction (83.8% obese vs. 81.9% non-obese).

Conclusions:

  • BMI status (obesity defined as BMI >95th percentile) does not significantly affect postoperative AHI outcomes following HNS implantation in pediatric DS patients.
  • HNS therapy is effective in reducing AHI in both obese and non-obese pediatric DS patients.
Abstract

Keywords:
down syndromehypoglossal nerve stimulationobesityoverweightpediatrics

More Related Videos

Control of Eating Behavior Using a Novel Feedback System04:48

Control of Eating Behavior Using a Novel Feedback System

Published on: May 8, 2018

10.9K
Sleeve Gastrectomy in Mice using Surgical Clips05:16

Sleeve Gastrectomy in Mice using Surgical Clips

Published on: November 14, 2020

6.5K

Related Concept Videos

Cranial Nerves: Types Part II01:22

Cranial Nerves: Types Part II

Cranial nerves are responsible for transmitting motor and sensory information between the brain and various parts of the body. There are twelve pairs of cranial nerves. While the first six innervate the head and neck, the latter six nerves innervate the head and neck, as well as organs and tissues in the thoracic and abdominal cavities. They facilitate communication, expression, and autonomic control within the human body.
Facial Nerve (Cranial Nerve VII)
Cranial nerve VII, or the facial nerve,...
Obesity01:24

Obesity

The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in adipocytes...
Drug Dosing: Obese Patients01:21

Drug Dosing: Obese Patients

In the United States, obesity is a prominent concern. It is linked to heightened mortality rates due to increased occurrences of conditions such as hypertension, atherosclerosis, coronary artery disease, and diabetes compared to nonobese individuals. A patient is classified as obese if their actual body weight surpasses the ideal or desirable body weight by 20%, based on Metropolitan Life Insurance Company data. Ideal body weights consider average weights and heights for males and females...