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Lewis Acid-Catalyzed Sulfur Fluoride Exchange
Theodore D Yassa1, Yuxin Fang1, Lana K Ravelo1
1Department of Chemistry, Pomona College, Claremont, California 91711, United States.
Abstract:
A new method uses metal Lewis acids as catalysts to convert sulfonyl fluorides, fluorosulfates, and sulfamoyl fluorides with silyl amines into S-N bond-containing compounds via sulfur fluoride exchange. The reaction successfully employs Ca(NTf2)2 as a catalyst to form sulfonamides, sulfamates, and sulfamides using in situ-generated or commercially available silyl amines in 35-99% yields. Other metal Lewis acids are also demonstrated to be catalysts in SuFEx, forming sulfonamides and sulfamates in yields comparable to those of Ca(NTf2)2.
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