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Connecting the changing trace elements spectrum and survival in sarcoma: a pilot study.

Laetitia Collet1,2,3, Philippe Telouk4, Francis Albarede4

  • 1Breast Cancer Translational Research Laboratory, Department of Medical Oncology, Institut Jules Bordet, Brussels, Belgium.

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Summary

This study analyzed serum metal and trace element levels in sarcoma patients, finding that elements like copper and potassium, along with their ratios, are linked to sarcoma progression and patient survival. These metallomic profiles offer insights into sarcoma biology.

Keywords:
CopperIsotopePrognostic factorsSarcomaTrace elements

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Area of Science:

  • Oncology
  • Metallomics
  • Biochemistry

Background:

  • Limited datasets exist on metal and trace element carcinogenicity.
  • Understanding the metallomic profile in sarcoma is crucial for diagnosis and prognosis.

Purpose of the Study:

  • To establish a trace element spectrum in sarcoma patients.
  • To correlate serum metal and trace element concentrations with survival data.

Main Methods:

  • Retrospective selection of 151 sarcoma patients and 59 controls from the International Sarcoma Kindred Study database.
  • Analysis of serum samples using Triple Quadrupole Inductively Coupled Plasma Mass Spectrometer (ICP-MS) and Multicollector MC-ICP-MS.
  • Statistical analysis using Wilcoxon rank sum test, log-rank test, and Cox regression models.

Main Results:

  • Significantly higher levels of Copper (Cu), Cu/Zn ratio, and K/Rb ratio in sarcoma patients compared to controls.
  • Elevated levels of these elements and ratios were also observed in advanced-stage sarcoma.
  • Potassium (K), Rubidium (Rb), Selenium (Se), Iron (Fe), Phosphorus (P), Silicon (Si), Sulfur (S), δ⁶⁵Cu, Cu, S/Se, and Cu/Zn ratio were independently associated with overall survival.

Conclusions:

  • The study presents a comprehensive metallomic spectrum for sarcoma.
  • Significant variations in metallomic profiles are associated with sarcoma patient survival.
  • These findings enhance the understanding of sarcoma biology and its potential therapeutic targets.