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Frailty in multiple sclerosis: A scoping review.

Nida' Al Worikat1, Farzan Molaei2, Anna Zanotto3

  • 1Department of Occupational Therapy Education, School of Health Professions, University of Kansas Medical Center, Kansas City, KS, United States; Department of Occupational Therapy, School of Rehabilitation Science, The University of Jordan, Amman, Jordan.

Multiple Sclerosis and Related Disorders
|November 9, 2024
PubMed
Summary
This summary is machine-generated.

Frailty is common in multiple sclerosis (MS), affecting 17-66% of patients and appearing earlier than in the general population. This review highlights frailty

Keywords:
AgingFrailtyMultiple sclerosisReview

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Area of Science:

  • Neurology
  • Gerontology
  • Rehabilitation Science

Background:

  • Frailty is an age-related condition increasingly recognized in neurological disorders.
  • Multiple sclerosis (MS) is a chronic neurological disease affecting young and middle-aged adults.
  • The impact of frailty on people with MS (pwMS) is an emerging area of research.

Purpose of the Study:

  • To conduct a scoping review on the prevalence, characteristics, and clinical outcomes of frailty in pwMS.
  • To synthesize current evidence on the association between MS clinical factors and frailty.
  • To identify the relationship between frailty and adverse outcomes in the MS population.

Main Methods:

  • Systematic literature search across major databases (PubMed, Scopus, Embase, etc.) and clinical trial registries.
  • Inclusion of studies published between 2000 and 2024, with no language restrictions.
  • Screening and selection of 11 studies (10 original articles, 1 conference paper) meeting predefined criteria.

Main Results:

  • Frailty is highly prevalent in pwMS, with reported rates from 17% to 66% in ambulatory patients.
  • PwMS exhibit an earlier onset of frailty compared to the general population, with mean participant ages between 41.2 and 58.6 years.
  • Higher disability, longer disease duration, progressive MS, reduced walking performance, poor sleep, fatigue, lower quality of life, falls, increased healthcare utilization, and mortality are associated with frailty in MS.

Conclusions:

  • Frailty is a prevalent and significant clinical issue in the multiple sclerosis population.
  • Early identification and management of frailty are crucial for improving outcomes in pwMS.
  • Further research is warranted to fully understand and address frailty in MS.