HPV is an essential driver in recurrence of cervical cancer
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View abstract on PubMed
Summary
This summary is machine-generated.High-risk human papillomavirus (HPV) is implicated in cervical cancer recurrence. Targeting HPV oncogenes may be a promising therapeutic strategy for metastatic disease.
Area Of Science
- Oncology
- Virology
- Genetics
Background
- High-risk human papillomavirus (HPV) DNA has been detected in distant metastases of cervical cancer (CC) patients.
- This suggests a potential role for HPV in the development and progression of CC, including recurrent disease.
Purpose Of The Study
- To investigate the presence and persistence of HPV DNA and RNA in primary and recurrent CC tissues.
- To analyze the expression of p16INK4a and the status of TP53 and RB1 mutations in relation to HPV status in CC recurrence.
Main Methods
- Next-generation sequencing (NGS) and immunohistochemical staining were employed.
- 26 patients with CC recurrence between 2019-2023 were included.
- Primary and matched recurrent tumor tissues were analyzed for HPV DNA/RNA, p16INK4a, and TP53/RB1 mutations.
Main Results
- All primary and recurrent CC tissues were positive for HPV DNA and RNA.
- High concordance (96.2%-100%) was observed for HPV DNA/RNA within primary and recurrent tissues.
- Strong agreement (88.5%-92.0%) was found between primary and recurrent tissues for HPV DNA/RNA detection. Most high-risk HPV-positive cases expressed p16INK4a, while the low-risk HPV11 case showed p16INK4a negativity and a TP53 mutation.
Conclusions
- High-risk HPV plays a significant role in recurrent cervical cancer.
- Findings support the exploration of targeting HPV oncogenes in CC treatment, including metastatic settings.
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