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Mechanism-based inactivators of sirtuin 5: A focused structure-activity relationship study

Tobias N Hansen1, Xinyi Yuan1, Marc S I Santana1

  • 1Center for Biopharmaceuticals & Department of Drug Design and Pharmacology, Faculty of Health and Medical Sciences, University of Copenhagen, Jagtvej 160, DK-2100 Copenhagen, Denmark.

Bioorganic & Medicinal Chemistry Letters
|November 9, 2024
PubMed
Summary

Researchers identified potent Sirtuin 5 (SIRT5) inhibitors, acting as mechanism-based inactivators. Prodrugs were developed to target SIRT5 within cells, offering potential for cancer therapies.

Keywords:
Enzyme inhibitorsEnzyme kineticsMechanism-based inactivationPosttranslational modificationSIRT5Sirtuins

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