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Related Experiment Videos

Stressor-provoked response patterns in a swim task: modification by diazepam.

C R Prince, C Collins, H Anisman

    Pharmacology, Biochemistry, and Behavior
    |February 1, 1986
    PubMed
    Summary

    Inescapable shock increases anxiety-like behaviors in mice, such as reduced swimming and increased avoidance. Diazepam treatment reduced these behavioral changes, suggesting anxiety modulation.

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    Area of Science:

    • Neuroscience
    • Animal Behavior

    Background:

    • Mice exhibit specific behaviors in novel environments and during stress.
    • Inescapable shock is a known stressor that can induce behavioral changes.

    Purpose of the Study:

    • To investigate the behavioral effects of inescapable shock in mice.
    • To explore the role of anxiety in these shock-induced behavioral changes.
    • To assess the anxiolytic effects of diazepam on these behaviors.

    Main Methods:

    • Mice were exposed to a forced-swim task and an illuminated arena test.
    • Behavioral responses, including swimming activity and exploration, were recorded.
    • Mice received diazepam administration before testing.

    Main Results:

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    • Inescapable shock enhanced vigorous responding and preference for illuminated areas.
    • Diazepam (0.5 and 1.0 mg/kg) reversed these shock-induced behavioral enhancements.
    • Floating posture in the forced-swim task was also affected.

    Conclusions:

    • Behavioral changes after uncontrollable shock may stem from transient increases in anxiety or vigilance.
    • Time-dependent behavioral alterations following inescapable shock are likely linked to anxiety level changes.
    • Diazepam demonstrates anxiolytic properties in this model.