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Causal association between COVID-19 vaccination and thrombosis-related biomarkers/thrombosis/ischemic stroke:

Xiaoqi Peng1, Lianjia Zhuo2, Yong Ma3

  • 1Department of Emergency, Shenzhen Hospital of Guangzhou University of Traditional Chinese Medicine (Futian), Shenzhen, 518034, Guangdong Province, PR China.

Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association
|November 9, 2024
PubMed

Insights

This study used Mendelian randomization to investigate COVID-19 vaccination effects. Genetically predicted vaccination showed potential causal links to ischemic stroke and large artery stroke risks.

Area of Science:

  • Genetics and Epidemiology
  • Cardiovascular Research
  • Infectious Disease Epidemiology

Background:

  • Inconsistent findings exist regarding COVID-19 vaccination and thrombosis/ischemic stroke.
  • Previous observational studies lack definitive causal evidence.

Purpose of the Study:

  • To assess the causal relationship between COVID-19 vaccination and thrombosis biomarkers, thrombosis, and ischemic stroke.
  • Utilizing Mendelian randomization (MR) to infer causality.

Main Methods:

  • Two-sample MR analysis using publicly available genome-wide association study (GWAS) data.
  • Inverse variance weighted (IVW) as the primary analysis method, with multiple sensitivity analyses.
  • Assessed genetic associations with thrombosis biomarkers (CCL3, MCFD2) and stroke outcomes.

Main Results:

  • Genetically predicted COVID-19 vaccination was associated with lower levels of CCL3 and MCFD2.
  • Significant causal effects were found between COVID-19 vaccination and increased risk of ischemic stroke and large artery stroke (LAS).
  • Sensitivity analyses confirmed the robustness of the findings, with no single SNP dominating the causal estimate.

Conclusions:

  • Evidence suggests a potential causal association between COVID-19 vaccination and altered CCL3/MCFD2 levels.
  • Findings indicate a possible causal link between COVID-19 vaccination and increased risk for ischemic stroke and LAS.
  • Further research is needed to elucidate mechanisms and validate these preliminary findings in diverse populations.
Abstract

Keywords:
COVID-19 vaccinationMendelian randomizationischemic strokethrombosisthrombosis-related biomarkers

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