Comprehensive review of LncRNA-mediated therapeutic resistance in non-small cell lung cancer

Area of Science:

• Molecular Biology
• Oncology
• Genetics

Background:

• Long non-coding RNAs (lncRNAs) are critical gene expression regulators.
• lncRNAs play significant roles in tumor initiation, progression, and therapeutic resistance.
• Aberrant lncRNA expression is linked to poor clinical outcomes in non-small cell lung cancer (NSCLC).

Purpose of the Study:

• To comprehensively review and identify lncRNAs associated with treatment responses in NSCLC.
• To categorize lncRNAs based on their mechanisms in mediating resistance to chemotherapy, targeted therapy, and radiotherapy.
• To provide mechanistic insights into heterogeneous treatment outcomes and identify potential therapeutic targets.

Main Methods:

• Literature review and comprehensive summary of existing research.
• Categorization of lncRNAs by their mechanisms of action in treatment resistance.
• Analysis of lncRNA roles in NSCLC development, metastasis, and therapeutic resistance.

Main Results:

• Various lncRNAs are aberrantly expressed in NSCLC, contributing to development, metastasis, and resistance.
• lncRNAs mediate resistance to chemotherapy, targeted therapy, and radiotherapy through diverse mechanisms.
• lncRNA dysregulation ultimately leads to poor clinical outcomes in NSCLC patients.

Conclusions:

• lncRNAs are pivotal in modulating therapeutic responses in NSCLC.
• Understanding lncRNA mechanisms can elucidate heterogeneous treatment outcomes.
• lncRNAs represent potential therapeutic targets for overcoming drug resistance in NSCLC.