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Updated: May 8, 2026
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Three-dimensional Imaging of Nociceptive Intraepidermal Nerve Fibers in Human Skin Biopsies
Published on: April 29, 2013
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Are symptoms in pathologic scars related to nerve function or density? A scoping review
M De Henau1, S Schins2, C Colla3
1Department of Plastic and Reconstructive Surgery, Maastricht University Medical Center, Maastricht, P Debyelaan 25, 6229 HX Maastricht, The Netherlands; GROW school for Oncology and Reproduction, Maastricht University, Universiteitssingel 40, 6229 ER Maastricht, the Netherlands.
Burns : Journal of the International Society for Burn Injuries
|November 10, 2024
Summary
Pathologic scars (PS) may involve nerve dysfunction, indicated by altered skin sensation and density. Neurogenic inflammation likely contributes to PS development and symptoms, though more research is needed.
Area of Science:
- Dermatology
- Neurology
- Pathology
Background:
- Hypertrophic scars and keloids are pathologic scars (PS) causing pain and itching.
- The relationship between nerve function, density, and PS symptoms is not well understood.
Purpose of the Study:
- To review current knowledge on nerve function and density in PS.
- To explore the association between sensory alterations, nerve density, and PS symptoms.
Main Methods:
- A scoping review was performed.
- Systematic searches were conducted in PubMed, Embase, and Web-of-Science.
- Relevant studies were selected and analyzed by two independent reviewers.
Main Results:
- Nineteen studies were included in the review.
- Sensibility in PS appears disturbed, with increased allodynia and altered thermosensory thresholds, suggesting small fiber neuropathy.
- Nerve fiber density varied, limiting direct comparisons, but neuropeptides may play a role in PS formation and symptoms.
Conclusions:
- Significant heterogeneity exists among studies, preventing firm conclusions.
- Evidence suggests the cutaneous nervous system, via neurogenic inflammation, is involved in PS pathophysiology and symptoms.
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