Recent advances in the use of essential oils and their nanoformulations for wound treatment

Despite progress in medical and surgical treatments of wounds, bioactive compounds still offer an effective and safe approach to accelerate wound healing (WH). In this review, recent results of studies on WH by essential oils (EOs) and their terpenoids are reported. Mechanisms of action of these substances and their possible use in drug delivery systems (DDSs) for WH are discussed. EOs of 38 species from 16 families have been evaluated for their potential to treat wounds. Lamiaceae was the most representative family with 10 species, followed by Myrtaceae and Asteraceae. EOs improve WH by acting as anti-inflammatory, antioxidant, and antimicrobial agents. Some other EOs were involved by increasing expression of transforming growth factor (TGF), inhibition of several factors, including plasminogen activator inhibitor-1 (PAI-1), substitution of type III collagen by type I collagen, and up-regulation of insulin-like growth factor-1 (IGF-1), fibroblast growth factor 2 (FGF-2), and vascular endothelial growth factor (VEGF). These mechanisms improved repair of cells and increased proliferation. Alternatively, DDSs based on nanomaterials (NMs) used to carry EOs for WH are mainly based on nanoparticles (NPs), microparticles (MPs) and scaffolds. There is much evidence that EOs can promote WH. Advancement of nanotechnology in recent years has contributed to improving use of EO with DDSs in WH management. However, some limitations need to be addressed to achieve the translation of this technology into clinical applications for wound treatment.