Area of Science:

• Cardiology
• Electrophysiology
• Medical Diagnostics

Background:

• Anterior ST elevation myocardial infarction (STEMI) poses a significant risk of life-threatening ventricular arrhythmias and sudden cardiac death.
• Early identification of high-risk patients is crucial for timely intervention and improved outcomes.

Purpose of the Study:

• To evaluate the predictive capability of the Tpeak-to-Tend (TpTe) interval and the TpTe/QT ratio for in-hospital ventricular arrhythmias and arrhythmic death in anterior STEMI patients.
• To determine if these electrocardiographic parameters can serve as early warning markers for adverse arrhythmic events.

Main Methods:

• An observational, cross-sectional study involving anterior STEMI patients presenting within 12 hours of symptom onset and undergoing primary percutaneous coronary intervention (pPCI).
• Data collected included clinical history, vital signs, electrocardiogram (ECG) measurements (including TpTe and QT intervals), left ventricular ejection fraction (LVEF), and pPCI details.
• Primary endpoints were sustained ventricular arrhythmias and all-cause or arrhythmic deaths during hospitalization.

Main Results:

• Patients experiencing arrhythmic events showed significantly higher QT dispersion, TpTe interval, TpTe/QT ratio, and rates of arrhythmic death (P < 0.05).
• Multivariate logistic regression identified the heart rate (HR), TpTe interval, and TpTe/QT ratio as significant independent predictors of arrhythmic events or mortality (P < 0.05).
• Specifically, the TpTe/QT ratio demonstrated a strong association (OR = 5.464, P = 0.001).

Conclusions:

• The Tpeak-to-Tend (TpTe) interval and TpTe/QT ratio are significant predictors of in-hospital ventricular arrhythmias and arrhythmic death in patients with anterior STEMI.
• Elevated values of TpTe and TpTe/QT indicate an increased risk of these critical cardiac events, suggesting their utility in risk stratification.