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Updated: Jul 16, 2026
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Induction and Clinical Scoring of Chronic-Relapsing Experimental Autoimmune Encephalomyelitis
Published on: July 4, 2007
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Functional outcome after infectious encephalitis: a longitudinal multicentre prospective cohort study.
Pierre Fillâtre1, Alexandra Mailles2, Jean Paul Stahl3
1Intensive Care Unit, Centre Hospitalier Yves Le Foll, Saint Brieuc, France; INSERM, CIC 1414, Rennes, France.
Summary
Infectious encephalitis survivors often experience long-term functional deficits, with recovery taking months. Key factors influencing outcomes include age, immunosuppression, ICU admission, brain imaging, and the specific infectious agent.
Area of Science:
- Neurology
- Infectious Diseases
- Neuroscience
Background:
- Infectious encephalitis (IE) can lead to significant long-term neurological sequelae.
- Understanding the trajectory of functional recovery and associated risk factors is crucial for patient management.
Purpose of the Study:
- To describe the longitudinal functional outcomes in patients surviving infectious encephalitis.
- To identify risk factors associated with poor functional outcomes after IE.
Main Methods:
- Prospective cohort study (ENCEIF) including 322 patients followed for 1 year post-discharge.
- Functional outcome assessed using modified Rankin scale (mRS), cognitive function, and daily living activities.
- Multivariable mixed ordinal regression analysis used to identify risk factors for poor outcome.
Main Results:
- At 12 months, 49% of patients had fully recovered, while 43% had persistent symptoms.
- Significant improvement was observed between 6 and 12 months post-discharge (24%).
- Factors associated with poor outcome included older age, immunosuppression, ICU admission, abnormal brain imaging, and specific causative agents like herpes simplex virus 1.
Conclusions:
- Functional recovery after infectious encephalitis can extend beyond 6 months.
- Baseline health status, disease severity indicators (ICU admission, brain imaging), and causative agents are significant predictors of functional outcome.
Keywords:
Functional outcomeHerpes simplex virusInfectious encephalitisSequelaeVaricella zoster virusMore Related Videos
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