Focal fatty infiltration of the liver simulating metastatic disease

Two cases are reported in which multiple, well-defined lesions of the liver, as seen on computed tomographic (CT) scans and sonograms, were thought to represent metastatic malignancy. Results from radionuclide scans and biopsies (and surgery in one case) indicated the correct diagnosis was fatty infiltration of the liver. Focal fatty infiltration should be considered in cases of multiple discrete hepatic lesions, especially in patients with a predisposing condition. Radionuclide studies and biopsies may be needed to confirm the diagnosis by CT.