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Updated: Jun 7, 2025

Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
Immunotherapies in breast cancer: harnessing the cancer immunity cycle
Vincent Lok1,2, Sy Olson-McPeek2, Grace Spiegelhoff2
1University of South Florida Morsani College of Medicine, Tampa, FL, USA.
Introduction:
Immunotherapies have found limited success in breast cancerdue to significant challenges within the tumor that block T-cell activity and function.
Areas Covered:
The current review discusses clinically relevant immunotherapeutics and trials within the framework of the cancer-immunity cycle.
Expert Opinion:
Current therapies such as antibody-drug conjugates and immune checkpoint blockade require proper biomarker selection, such as PD1 expression and the degree of tumor-infiltrating lymphocyte (TIL) infiltration to subset potential responders. HER2 and other tumor-associated antigens have served as valuable benchmarks for developing novel therapies, such as antibody engagers and CAR T-cells. However, further research is essential to identify and validate new target antigens that can enhance therapeutic efficacy and broaden the clinical applicability of these approaches.
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