Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Biotinylated Silatrane: Development Functional Organosilicon Biointerfaces for Molecular Detection.

ACS applied materials & interfaces·2026
Same author

Molecular Design in Dynamic (Meth)acrylic Cross-linkers for Tough, Self-healing, and Recyclable Elastomer.

Macromolecules·2026
Same author

Single-molecule DNA flow-stretch assays for high-throughput DNA-protein interaction studies.

FEBS open bio·2026
Same author

Machine Learning-Guided Design of High-Performance Antifungal Polymers against <i>Candida albicans</i>.

ACS polymers Au·2025
Same author

Effects of Anion Coadsorption on the Self-Assembly of 11-Acryloylamino Undecanoic Acid on an Au(111) Electrode.

ACS omega·2024
Same author

Noninvasive Prenatal Genetic Screening of Cell-Free Fetal DNA for Early Prediction of β-Thalassemia Using Fiber Optic Nanogold-Linked Sorbent Assay.

ACS sensors·2024
Same journal

Asymmetric Interfacial Dynamics during Oblique Impact of Two Unequal-Sized Nanodroplets on Superhydrophobic Surfaces.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Anion-Induced Surface Curvature for Modulating Electronic Structures to Enhance Aqueous-Phase C-C Coupling toward Biofuel Precursors.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Impact Dynamics and Heat Exchange of Cold Droplet on Supercooled Macrotextured Nonwettable Surfaces.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Surface Potential and Surface Dipole Moment of Water and Polar-Quadrupolar Liquids.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Particle Size-Driven Transition from Multilayer Aggregates to Ordered Monolayers at Gas Marble Interfaces.

Langmuir : the ACS journal of surfaces and colloids·2026
Same journal

Correction to "Molecular Engineering of Calixarene Dyes on UiO-66-NH<sub>2</sub>: Boosting Electron Transfer for High-Efficiency Photocatalytic Hydrogen Evolution".

Langmuir : the ACS journal of surfaces and colloids·2026
See all related articles

Related Experiment Video

Updated: Jun 7, 2025

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

16.7K

Development of Functional Biointerface Using Mixed Zwitterionic Silatranes.

Thi Anh Hong Tran1,2, Van Truc Vu2, Chun-Jen Huang2,3

  • 1Department of Biomedical Sciences and Engineering, National Central University, Jhong-Li, Taoyuan 320, Taiwan.

Langmuir : the ACS Journal of Surfaces and Colloids
|November 11, 2024
PubMed
Summary
This summary is machine-generated.

Novel oligomeric silatranes, mercaptopropylsilatrane-zwitterionic monomer (MPS-MPC) and MPS-carboxylated poly(ethylene glycol) methacrylate (MPS-PEGMACOOH), were developed for advanced biosensor interfaces. These coatings reduce nonspecific adsorption and enable biomolecule conjugation for improved biosensor performance.

More Related Videos

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

9.4K
Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.1K

Related Experiment Videos

Last Updated: Jun 7, 2025

Bridging the Bio-Electronic Interface with Biofabrication
16:38

Bridging the Bio-Electronic Interface with Biofabrication

Published on: June 6, 2012

16.7K
Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification
07:32

Synthesis of Hydrogels with Antifouling Properties As Membranes for Water Purification

Published on: April 7, 2017

9.4K
Preparation of Functional Silica Using a Bioinspired Method
08:04

Preparation of Functional Silica Using a Bioinspired Method

Published on: August 1, 2018

17.1K

Area of Science:

  • Materials Science
  • Biotechnology
  • Surface Chemistry

Background:

  • Biosensor performance is challenged by background signals from clinical samples.
  • Polymer coatings are crucial for tailoring biointerfaces and improving biosensor functionality.
  • Developing effective strategies for multifunctional biosensor interfaces is essential.

Purpose of the Study:

  • To introduce novel oligomeric silatranes for creating advanced biosensor interfaces.
  • To evaluate the coating properties and biofouling resistance of these new materials.
  • To demonstrate the utility of these coatings for biomolecule conjugation and enhanced biosensing.

Main Methods:

  • Copolymerization of mercaptopropylsilatrane (MPS) with MPC and PEGMACOOH via thiol-ene polymerization.
  • Deposition of oligomeric silatranes on silicon wafers.
  • Characterization of coating properties (wettability, thickness, elemental composition) using contact angle meter, ellipsometry, and XPS.
  • Evaluation of nonspecific adsorption (NSA) and signal discrimination using enzyme-linked immunosorbent assay (ELISA).

Main Results:

  • MPS-MPC polymers formed hydrophilic films with excellent fouling repulsion against bacteria and proteins.
  • A mixed coating (70% MPS-PEGMACOOH, 30% MPS-MPC) showed the thinnest coating and best wettability among COOH-terminated coatings.
  • The mixed coating significantly reduced NSA and improved signal discrimination in ELISA.
  • Functional COOH groups allowed for postmodification with biomolecules via NHS ester chemistry.

Conclusions:

  • Novel mixed oligomeric silatranes offer a promising approach for biosensor interface design.
  • These coatings provide dual functions: prevention of nonspecific binding and conjugation of biomolecules.
  • The developed materials enhance biosensor sensitivity, specificity, and accuracy by minimizing interference.