Prevalence of cardiometabolic diseases in underweight: a nationwide cross-sectional study

Meng Chen1, Shuxiao Shi1, Sujing Wang1

  • 1Department of Epidemiology and Biostatistics, School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai200025, People's Republic of China.

PubMed

Insights

Nearly half of US adults with underweight have cardiometabolic diseases (CMD). A significant 12.3% have two or more CMD, highlighting a critical public health challenge.

Area of Science:

  • Public Health
  • Cardiology
  • Endocrinology

Background:

  • Cardiometabolic diseases (CMD) pose a significant health burden.
  • Underweight individuals are often overlooked in CMD prevalence studies.
  • Understanding CMD prevalence in underweight populations is crucial for targeted interventions.

Purpose of the Study:

  • To estimate the nationwide prevalence of various cardiometabolic diseases (CMD) among adults with underweight in the US.
  • To assess the prevalence of zero or at least two CMD in this population.
  • To identify potential disparities in CMD prevalence among different demographic subgroups.

Main Methods:

  • Utilized data from the National Health and Nutrition Examination Survey (1999-2020).
  • Estimated age-standardized prevalence of dyslipidemia, hypertension, diabetes, chronic kidney disease, and cardiovascular disease (CVD).
  • Employed multivariable Poisson regressions to compare CMD prevalence across subgroups, adjusting for covariates.

Main Results:

  • Among 855 underweight adults, 23.4% had dyslipidemia, 15.6% hypertension, 2.5% diabetes, 7.9% chronic kidney disease, and 6.1% CVD.
  • 50.6% had zero CMD, while 12.3% had at least two CMD.
  • Non-Hispanic Black adults showed a significantly higher prevalence of diabetes compared to non-Hispanic White adults.

Conclusions:

  • Approximately half of US adults with underweight have at least one CMD.
  • A notable 12.3% of underweight adults have two or more CMD, indicating a substantial disease burden.
  • The prevention and management of CMD in underweight adults represent a critical, yet often neglected, public health issue.

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