Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Jun 7, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.4K

Elevated reactive aggression in forebrain-specific Ccn2 knockout mice.

Ho-Ching Chang1, Chi-Hou Ng1, Yu-Fu Chen2

  • 1College of Medicine Graduate Institute of Anatomy and Cell Biology National Taiwan University Taipei Taiwan.

Journal of Cell Communication and Signaling
|November 11, 2024
PubMed
Summary

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of the COVID-19 Pandemic Peak and Post-pandemic Period on Healthcare Professionals' Attitudes Toward Patient Safety Culture: A Comparative Study.

Safety and health at work·2026
Same author

Deletion of Fbxo25 causes excessive repetitive behavior, impaired recognition memory, reduced dendritic complexity, and aberrant protein expression in mice.

Progress in neurobiology·2026
Same author

A 6-year latent profile analysis of teamwork climate, job satisfaction, and emotional exhaustion among healthcare workers at a Taiwanese medical center.

Nursing outlook·2026
Same author

Endoscopic variceal ligation versus cyanoacrylate injection for acute variceal bleeding from the cardia to the lesser curvature.

Journal of the Chinese Medical Association : JCMA·2026
Same author

Direct Chemical Reprogramming of Human Fibroblasts into Retinal Progenitor-like Cells for Ocular Delivery.

Journal of functional biomaterials·2026
Same author

Amyloid pathology and modifiable risk factors in cognitive decline among cognitively unimpaired older adults.

The journal of prevention of Alzheimer's disease·2026
This summary is machine-generated.

Forebrain-specific knockout of cellular communication network factor 2 (CCN2) in male mice resulted in increased anxiety and reactive aggression. This suggests CCN2

Area of Science:

  • Neuroscience
  • Molecular Biology
  • Behavioral Genetics

Background:

  • Cellular communication network factor 2 (CCN2) is a matricellular protein with known roles in connective tissue.
  • CCN2 is expressed in the nervous system, but its specific functions in the brain remain largely uncharacterized.
  • Understanding CCN2's role in the brain is crucial for elucidating neural communication and behavior.

Purpose of the Study:

  • To investigate the function of CCN2 in the brain by examining the behavioral phenotypes of forebrain-specific Ccn2 knockout (FbCcn2 KO) mice.
  • To explore the neural mechanisms underlying aggression and anxiety related to CCN2 deficiency in the forebrain.
  • To establish a mouse model for studying reactive aggression and potential therapeutic strategies.

Main Methods:

Keywords:
c‐fosmedial amygdalaolfactory systemprefrontal cortexresident‐intruder test

More Related Videos

Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

368
Elevated Plus Maze for Mice
09:09

Elevated Plus Maze for Mice

Published on: December 22, 2008

90.5K

Related Experiment Videos

Last Updated: Jun 7, 2025

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice
07:15

Author Spotlight: Understanding Adolescent Social Adversity Effects on Neurodevelopment in Mice

Published on: March 15, 2024

1.4K
Chronic Social Defeat Stress in Early Adolescent Male Mice
07:06

Chronic Social Defeat Stress in Early Adolescent Male Mice

Published on: January 24, 2025

368
Elevated Plus Maze for Mice
09:09

Elevated Plus Maze for Mice

Published on: December 22, 2008

90.5K
  • Generation of forebrain-specific Ccn2 knockout (FbCcn2 KO) mice.
  • Assessment of behavioral phenotypes including locomotion, sensorimotor gating, social behavior, anxiety, and reactive aggression.
  • Analysis of c-fos expression in aggression-related brain regions (medial amygdala and prefrontal cortex) following the resident-intruder task (RIT).

Main Results:

  • Male FbCcn2 KO mice displayed normal locomotion, sensorimotor gating, and social behaviors.
  • FbCcn2 KO mice exhibited increased signs of anxiety and elevated reactive aggression.
  • RIT-induced c-fos expression was higher in the medial amygdala but lower in the prefrontal cortex of FbCcn2 KO mice compared to controls.

Conclusions:

  • Loss of CCN2 in the forebrain, particularly in olfaction-related regions, enhances olfactory social cue signaling in the medial amygdala, leading to increased reactive aggression.
  • Reduced CCN2 in the prefrontal cortex may impair inhibitory control and emotion regulation, contributing to anxiety and aggressive behavior.
  • The FbCcn2 KO mouse model provides insights into the mechanisms of reactive aggression and potential therapeutic interventions.