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A Patient-Derived Xenograft Model for Venous Malformation
Published on: June 15, 2020
Pearls and Pitfalls in the Management of Vascular Anomalies
Omar Sanon1, Andrew Henderson1, Robert J Rosen2
1Division of Vascular Surgery, Lenox Hill Hospital, Northwell Health, New York.
Abstract:
Recent advancements in endovascular techniques have transformed the management of vascular malformations, shifting away from traditional surgical resections to less invasive methods like embolization and sclerotherapy. Vascular malformations are congenital anomalies resulting from embryonic angiogenesis failures, often misdiagnosed but manageable through a multidisciplinary approach. These malformations range from high-flow arteriovenous connections to low-flow venous, lymphatic, or mixed lesions, each requiring specific diagnostic and treatment strategies. Specific syndromes like Klippel-Trenaunay and Parkes-Weber require tailored approaches due to their unique presentations. Diagnosis relies on a combination of physical examination and advanced imaging techniques, including ultrasound and MRI. Treatment is focused on symptomatic relief and improving the patient's quality of life. Interventional treatment is indicated when conservative and/or medical management is insufficient. Surgical interventions remain relevant for select cases, often in a multidisciplinary context. Newer therapies, such as sirolimus, are emerging for complex, treatment-resistant cases.

