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Circulating chemerin and interleukin-6 in children with obesity: possible metabolic risk predictors
Jie Zhang1,2, Cai Gu1,3, Meiling Deng1,4
1Department of Pediatrics, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Insights
Elevated levels of interleukin-6 (IL-6) and chemerin in obese children correlate with metabolic risks. These biomarkers may serve as early predictors for childhood obesity and its complications.
Area of Science:
- Pediatrics
- Metabolic Health
- Biomarker Discovery
Background:
- Childhood obesity incidence is rising, posing significant adult health risks.
- Early detection and prevention strategies are crucial for managing childhood obesity.
- Interleukin-6 (IL-6) and chemerin are investigated as potential indicators.
Purpose of the Study:
- To assess serum levels of IL-6 and chemerin in children with obesity.
- To explore the clinical significance of these biomarkers in childhood obesity.
- To identify potential early warning predictors for obesity-related complications.
Main Methods:
- A case-control study involving 101 children (50 obese, 51 healthy).
- Measurement of serum chemerin and IL-6 levels.
- Correlation analysis with metabolic parameters and multivariate regression.
Main Results:
- Obese children showed significantly higher levels of chemerin, IL-6, BMI, and various metabolic indicators (e.g., TG, LDL, HbA1c, HOMA-IR).
- HDL levels were lower in the obese group.
- Serum chemerin and IL-6 positively correlated with BMI, insulin resistance markers, and liver enzymes; IL-6 was an independent determinant of chemerin.
Conclusions:
- Elevated serum chemerin and IL-6 in obese children are linked to adverse metabolic profiles.
- These biomarkers may play a role in the development of childhood obesity and its complications.
- Chemerin and IL-6 show promise as early warning predictors for metabolic risks in children.
Background:
As the incidence of childhood obesity has risen significantly and it can result in many complications in adulthood, this study aimed to provide a new view for early prevention of childhood obesity by detecting the levels of interleukin-6 (IL-6) and chemerin in children and studying the clinical significance.
Methods:
We used a case-control design. Serum chemerin and IL-6 levels were measured among 101 participants, including 50 children with obesity and 51 healthy children. Chemerin and IL-6 were correlated with metabolic parameters, and the independent determinants of chemerin and IL-6 were studied by using multivariate linear regression analysis.
Results:
The levels of chemerin, IL-6, body mass index (BMI), blood pressure, triglyceride (TG), low-density lipoprotein (LDL), hemoglobin A1c (HbA1c), Fins, C-peptide, homeostasis model assessment of insulin resistance (HOMA-IR), aspartate aminotransferase (AST), alanine aminotransferase (ALT), uric acid and creatinine were significantly increased in children with obesity (P<0.05). While, the levels of high-density lipoprotein (HDL) in the obese group were remarkably lower (P<0.05). The correlative analysis showed that serum chemerin and IL-6 were positively correlated with BMI, Fins, C-peptide, HOMA-IR, and AST, and chemerin was also positively correlated with systolic blood pressure, ALT, and IL-6 (P<0.05). Multivariate linear regression analysis showed that IL-6 was the independent determinant of chemerin.
Conclusions:
The elevated levels of serum chemerin and IL-6 in children with obesity were positively correlated with multiple metabolic indicators, suggesting that chemerin and IL-6 may be involved in the occurrence of childhood obesity and its complications, and were expected to become early warning metabolic risk predictors.
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