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Prognostic factors and surgical management in pediatric primary lung cancer: a retrospective cohort study using SEER data

  • 0Department of Pediatric Surgery, Fujian Children's Hospital (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Translational Pediatrics +

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November 11, 2024

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November 11, 2024

View abstract on PubMed

Summary

This summary is machine-generated.

Pediatric lung cancer (LC) prognosis depends on pathology, stage, surgery, and tumor size. Surgery may not benefit advanced-stage LC, but aids those with lymph node metastasis. Tailoring treatment is key for better outcomes.

Area Of Science

  • Pediatric Oncology
  • Thoracic Surgery
  • Cancer Epidemiology

Background

  • Primary lung cancer (LC) is rare in children, lacking established treatment guidelines and extensive research.
  • Diagnosis and management of pediatric LC present unique challenges due to its rarity.
  • Limited data exists on prognosis and treatment experiences for pediatric lung cancer patients.

Purpose Of The Study

  • To evaluate prognostic factors in pediatric primary lung cancer patients.
  • To assess the survival benefits of surgical intervention in this population.
  • To identify key determinants influencing outcomes in pediatric lung cancer.

Main Methods

  • Utilized the Surveillance, Epidemiology, and End Results (SEER) database (1988-2019).
  • Analyzed data from 337 children (0-19 years) diagnosed with primary lung cancer.
  • Employed univariate and multivariate Cox regression for prognostic marker evaluation and Kaplan-Meier curves for survival analysis.

Main Results

  • Pathologic classification, SEER stage, surgery, and tumor size were independent prognostic factors.
  • Worse prognosis associated with specific types (pulmonary/pleuropulmonary blastoma, adenocarcinoma), no surgery, and larger tumors (≥5 cm).
  • Localized SEER stage, carcinoid tumors, and lymph node dissection improved survival; surgery benefit varied by stage and tumor size.

Conclusions

  • Pathology, SEER stage, surgery, and tumor size are critical prognostic indicators for pediatric LC.
  • Surgical intervention may not improve survival in advanced-stage pediatric lung cancer.
  • Personalized therapeutic strategies based on histology, stage, and size are essential for optimizing pediatric LC patient outcomes.

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