Segmental chromosome aberrations as a prognostic factor of neuroblastoma: a meta-analysis and systematic review
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View abstract on PubMed
Summary
This summary is machine-generated.Segmental chromosome aberrations like 1p loss, 11q loss, and 17q gain are significant predictors of poor prognosis in neuroblastoma patients. These genetic changes impact overall survival and event-free survival rates, highlighting their importance in treatment strategies.
Area Of Science
- Genetics
- Oncology
- Molecular Biology
Background
- Segmental chromosome aberrations are linked to poor prognosis in neuroblastoma.
- These aberrations include chromosomal arm deletions or imbalances.
- Identifying these markers is crucial for predicting patient outcomes.
Purpose Of The Study
- To quantitatively analyze hazard ratios (HRs) of chromosome aberrations.
- To assess the impact of aberrations on overall survival (OS) and event-free survival (EFS).
- To provide a meta-analysis of prognostic predictors in neuroblastoma.
Main Methods
- Systematic search of PubMed, Embase, and Web of Science databases.
- Inclusion of studies published up to April 2023.
- Risk of bias assessment using the Quality In Prognosis Studies tool.
- Meta-analysis using a random effects model to pool HRs.
Main Results
- 34 studies including 14,356 patients were analyzed.
- Pooled HR for 1p loss: 4.46 for EFS and 2.29 for OS.
- Pooled HR for 17q gain: 4.81 for EFS and 3.98 for OS.
- Pooled HR for 11q loss: 2.54 for OS.
- Other aberrations' effects were also summarized.
Conclusions
- 1p loss, 11q loss, and 17q gain are significant independent predictors.
- These aberrations predict long-term OS and EFS in neuroblastoma patients.
- Findings emphasize the prognostic value of specific chromosomal changes.
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