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Published on: August 2, 2024
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LncRNAs modulating tooth development and alveolar resorption: Systematic review.
Lilliane Aol1, Xinhong Zhou1, Hong Hao2
1Key Laboratory of Molecular Biophysics of Ministry of Education, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China.
Heliyon
|November 11, 2024
Summary
Long non-coding RNAs (LncRNAs) regulate tooth development and alveolar bone loss. These molecules interact with microRNAs and signaling pathways, offering potential therapeutic targets for oral disorders.
Area of Science:
- Molecular Biology
- Genetics
- Oral Biology
Background:
- Tooth development involves complex cellular and molecular processes.
- Disruptions can cause structural anomalies and increase oral disease risk.
- Alveolar bone loss in periodontitis is a significant clinical issue.
Purpose of the Study:
- To review recent findings on molecular mechanisms in tooth development and alveolar resorption.
- To explore the role of long non-coding RNAs (LncRNAs) in these processes.
- To understand the impact of LncRNAs on gene expression and oral health.
Main Methods:
- Systematic review of current research on LncRNAs.
- Analysis of LncRNA interactions with chromatin regulators, enhancers, and microRNAs (miRNAs).
- Examination of LncRNA involvement in signaling pathways.
Main Results:
- LncRNAs regulate gene expression at transcriptional and post-transcriptional levels.
- LncRNAs, like ZFAS1, impact tooth development and alveolar resorption.
- LncRNA-miRNA interactions modulate downstream gene expression relevant to oral health.
Conclusions:
- LncRNAs are key regulators in tooth development and alveolar bone remodeling.
- Understanding LncRNA mechanisms offers insights into treating periodontal diseases.
- LncRNAs present potential therapeutic targets for oral health interventions.
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