Identifying functional cuproptosis-related long non-coding RNAs in patients with bladder cancer
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View abstract on PubMed
Summary
This summary is machine-generated.This study reveals cuproptosis-related long non-coding RNAs (lncRNAs) are key in bladder cancer development. A new prognostic signature using these lncRNAs can predict patient survival and guide treatment strategies.
Area Of Science
- Oncology
- Molecular Biology
- Genetics
Background
- Bladder cancer is a prevalent urinary tract malignancy worldwide.
- Cuproptosis, a novel cell death pathway, is implicated in cancer development.
- Understanding cuproptosis-related genes is crucial for bladder cancer research.
Purpose Of The Study
- To investigate the correlation between cuproptosis-related genes and bladder cancer tumorigenesis.
- To develop a prognostic signature for bladder cancer based on cuproptosis-related long non-coding RNAs (lncRNAs).
- To evaluate the predictive power of the developed signature for patient survival.
Main Methods
- Utilized Pearson correlation and univariate Cox regression on The Cancer Genome Atlas (TCGA) data.
- Employed Least Absolute Shrinkage and Selection Operator (LASSO) Cox regression to build a prognostic signature.
- Generated a nomogram for predicting individual patient survival outcomes.
Main Results
- Identified 19 cuproptosis-related genes and 14 prognostic cuproptosis-related lncRNAs.
- Developed a seven-lncRNA prognostic risk signature with good predictive accuracy (1-, 3-, 5-year AUCs: 0.711, 0.673, 0.684).
- High-risk group showed worse prognosis, linked to tumorigenesis, migration, high chemokines, T-cell inhibition, and low antigen-presenting cells.
Conclusions
- Cuproptosis-related lncRNAs play a significant role in bladder cancer tumorigenesis.
- These lncRNAs represent potential therapeutic targets for bladder cancer.
- An individualized predictive signature based on cuproptosis-related lncRNAs was successfully constructed.
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