An Interesting Case of Weil's Disease with Diagnostic Challenges

Weil's disease represents a rare, severe form of leptospirosis, characterized by high mortality risk. The clinical presentation ranges from a self-limited febrile illness to a more severe form of infection where patients may have multiorgan failure. Here we present a case of a young immigrant with abdominal pain, vomiting, and body aches, presenting with mixed hyperbilirubinemia, acute kidney injury (AKI), and moderate thrombocytopenia. Imaging revealed granulomatous pneumonic changes. Despite negative initial studies, the combination of the cholestatic pattern of liver injury, thrombocytopenia, pulmonary and renal involvement, along with recent travel and occupation history, raised concern for leptospirosis. A positive Leptospira IgM explained the diverse presentation, emphasizing the need to consider uncommon infectious etiologies and conduct a thorough, comprehensive evaluation for accurate diagnosis and successful management.